Situated in the Kritika, the S. Nikolis Hotel is close to Andreas Papandreou Park and University of Aegean. The hotel is situated in the centre of Rhodes and is within an easy walk from Diagoras Stadium, Archaeological Museum of Rhodes and Governors Palace. Rhodes's attractions, such as Palazzo Del Gran Maestro, Park of Saint Fragkiskos and Kahal Shalom Synagogue are within an easy walking distance.

The S. Nikolis Hotel caters for families with children offering babysitting / child services. Facilities at the hotel include a business centre, a 24 hour reception and a dry cleaning service. Facilities offered include a laundry service, a currency exchange and a safe-deposit box.